BRCA1 | WCRF

The Way Forward Is Clearer, Together.

The Women’s Cancer Research Foundation (WCRF) annually publishes and funds numerous clinical studies on breast and gynecologic (ovarian, endometrial, and cervical) cancers. The WCRF’s oncology experts work tirelessly with the belief that each new clinical study has the potential to fundamentally improve the outcomes of patients diagnosed with breast and gynecologic cancers.

The Risks of Cancer in Older Women with BRCA Pathogenic Variants: How Far Have We Come?

Women's Cancer Research Foundation

Feb 3, 20232 min read

The Risks of Cancer in Older Women with BRCA Pathogenic Variants: How Far Have We Come?

In a recent study, investigators estimated the cumulative risks of all cancers in women from 50 to 75 years of age who were diagnosed with..

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Women's Cancer Research Foundation

Jul 26, 20222 min read

Prevention of Ovarian Cancer

Risk reduction for women who carry BRCA1/2 mutations can achieve a 95% reduced risk of ovarian cancer through a risk-reducing...

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Risk of Peritoneal Cancer After Risk-Reducing Bilateral Salpingo-Oophorectomy for Women

Women's Cancer Research Foundation

Jul 11, 20222 min read

Risk of Peritoneal Cancer After Risk-Reducing Bilateral Salpingo-Oophorectomy for Women

The average lifetime risk of developing ovarian cancer risk for women who harbor a BRCA1 or BRCA2 pathogenic germline mutation is 44% & 17%

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Contraceptive Use and the Risk of Ovarian Cancer Among Women With a BRCA1 or BRCA2 Mutation

Women's Cancer Research Foundation

Jun 15, 20222 min read

Contraceptive Use and the Risk of Ovarian Cancer Among Women With a BRCA1 or BRCA2 Mutation

Women with a BRCA1 and BRCA2 mutation have a higher lifetime risk of developing ovarian cancer.

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Cancer Risks Associated with BRCA1 and BRCA2 Pathogenic Variants

Women's Cancer Research Foundation

Apr 7, 20221 min read

Cancer Risks Associated with BRCA1 and BRCA2 Pathogenic Variants

In a recent study, age-specific risk estimates of cancers, excluding breast and ovarian cancer, associated with pathogenic variants in...

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Breast Cancer Surveillance Following Ovarian Cancer in BRCA Mutation Carriers

Women's Cancer Research Foundation

Mar 28, 20221 min read

Breast Cancer Surveillance Following Ovarian Cancer in BRCA Mutation Carriers

Women with a BRCA 1 or 2 mutation carriers have an increased risk of developing breast cancer and ovarian cancer. However....

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Oral Contraceptives May Reduce Risk of Ovarian Cancer in BRCA Carriers

Women's Cancer Research Foundation

Oct 22, 20211 min read

Oral Contraceptives May Reduce Risk of Ovarian Cancer in BRCA Carriers

Analyses showed a longer duration of contraceptive use and more recent use were associated with a greater reduction in ovarian cancer risk.

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Risk of Late-Onset Breast Cancer in Genetically Predisposed Women

Women's Cancer Research Foundation

Oct 12, 20211 min read

Risk of Late-Onset Breast Cancer in Genetically Predisposed Women

Germline mutations in breast cancer predispose women to develop this malignancy, but in woman 65+years, the risk is not well-defined.

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Drug Boosts Survival for Women with Advanced Ovarian Cancer

Women's Cancer Research Foundation

Aug 5, 20211 min read

Drug Boosts Survival for Women with Advanced Ovarian Cancer

Lynparza (Olaparib), a targeted cancer therapy, has recently shown a meaningful survival benefit after 5 years.

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Endometrial Cancer Risk in Women Diagnosed with a Germline BRCA1 or BRCA2 Mutation

Women's Cancer Research Foundation

Apr 7, 20212 min read

Endometrial Cancer Risk in Women Diagnosed with a Germline BRCA1 or BRCA2 Mutation

BRCA1 and BRCA2 are genes that produce proteins that help repair damaged DNA (a person’s unique genetic code).

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